In this talk we first recall the classical variational framework for SPDE and some recent development, then we present the well-posedness result of stochastic PDE with time-fractional derivative based on the variational approach/monotonicity techniques. Applications include deterministic and stochastic quasi-linear partial differential equations with time-fractional derivatives, including time-fractional stochastic porous media equations and stochastic p-Laplace equations as special cases.