Disease progression is often monitored by intermittent follow-up visits in longitudinal cohort studies, resulting in time-to-event outcomes subject to interval censoring. Furthermore, the timing and frequency of clinical visits are often found related to a person's history of disease-related variables such as disease progression and treatment, thus producing outcome-dependent observation times. Standard statistical methods for interval-censored data analysis reply on the assumption that observation times are independent of the time-to-event outcome. Otherwise, selection bias will be induced. In this presentation, I will introduce a so-called inverse-intensity-of-visit (IIV) weighting approach which models observation times as a recurrent event process and incorporates the estimated visit intensities in the model of time-to-event outcome. Parametric, non-parametric and semi-parametric methods are specifically developed based on that. Simulations are conducted to examine the finite sample performance of the proposed estimators, compared with standard analysis methods. A dataset from the Toronto Psoriatic Arthritis (PsA) Cohort Study is used to illustrate the proposed methodologies.
朱雅媛 博士 毕业于同济大学数学系统计学专业,后于加拿大卡尔加里大学数学系和滑铁卢大学统计精算系获得理学硕士与博士学位。之后曾在德州大学安德森癌症中心从事两年的博士后研究。 现于加拿大西安大路大学流行病学与生物统计学系任助理教授。其主要研究方向是生存分析,纵向数据分析,及动态预测模型在生物医学领域的应用。