Acquired tick resistance, an important host defense behavior against tick infestation, has not yet been modeled or qualitatively analyzed. In this study, we propose a tick-borne disease transmission model that incorporates ATR, in which hosts are categorized into subgroups based on their infection status and the number of tick bites. For the tick–host population model, we derive four distribution patterns of host subpopulations and analyze the global asymptotic stability of the positive equilibrium. For the disease transmission model, we calculate the basic reproduction number and prove the global asymptotic stability of both the disease-free equilibrium and the endemic equilibrium. Numerical simulations demonstrate that the emergence of ATR effectively reduces the number of infected hosts, whereas an increase in the co-feeding transmission probability leads to a rise in the number of infected ticks.